Table 2.

detection methods of included studies

Reference (year)	Region	Time Span	Gene	Methods	Generations of the detection method
Ford et al. (1994) [19]	North America and Western Europe	_	BRCA1-mutation	Typing of markers	First generation
Chen-Shtoyerman et al. (2001) [25]	Ashkenazi Jewish	_	BRCA1/2 germline mutations: 185delAG and 5382insC (BRCA1) and 6174delT (BRCA2)	PCR and restriction fragment length polymorphism	First generation
Thompson et al. (2002) [32]	Europe and North America	2002	BRCA1 mutation:185delAG and 5382insC	Mutation screening	First generation
Niell et al. (2004) [30]	Northern Israel	March 31,1998 to December 31, 2002	BRCA1 187delAG; BRCA1 5385insC; BRCA2 6174delT	PCR	First generation
Kirchhoff et al. (2004) [28]	Ashkenazi Jewish	March 31, 1994 to February 4, 2002	BRCA1 and BRCA2	PCR, IHC	First generation
Kadouri et al. (2007) [27]	Ashkenazi Jewish	1995 to 2003	BRCA1: 185delAG and 5382insC; BRCA2: 6174delT	Statistic analysis	First generation
Suchy et al. (2010) [31]	9 centers situated throughout Poland	1998 to 2008	BRCA1 founder mutations (C61G, 4153delA and 5382insC)	PCR	First generation
Phelan et al. (2014) [16]	50 centers in five countries (Canada, United States, Poland, France and Norway)	1992 to 2010	BRCA1 and BRCA2 mutation	Direct Sanger sequencing	First generation
Mersch et al. (2015) [29]	Clinical Cancer Genetics clinics at the UT MD Anderson Cancer Center (MDACC)	1997 to 2013	BRCA1 or BRCA2 deleterious mutation	Statistic analysis	First generation
Dobbins et al. (2016) [26]	UK	_	114 cancer susceptibility genes	High-coverage exome sequencing: Illumina HumanExome-12v1_A Beadchip arrays	Second generation
Fujita et al. (2020) [20]	Japan	2003 to 2018	27 cancer susceptibility genes	Multiplex PCR	First generation
Akcay et al. (2020) [24]	Turkish	November 2016 to December 2019	25 cancer susceptibility genes	next-generation sequencing-based multigene panel testing and multiplex ligation-dependent probe amplification testing	Second generation