Table 2.

Intervention Characteristics

Reference	Pre-operative Gabapentin	Dosage	Frequency of Administration	Duration of Administration
Anderson28	Yes	15 mg/kg pre-op / 10 mg/kg post-op	Once pre-op / TID post-op	Not stated pre-op / 5 days post-op
Badawy39	Yes	5 mg/kg pre-op	Once	1 hour pre-op
Baxter27	No	4.4–30.4 mg/kg/day post-op (median 10.1)	TID post-op	Not stated post-op
Choudhry21	Yes	Gabapentin10 mg/kg pre-op (maximum of 600mg) and 200 mg TID (if >50 kg) or 100 mg TID (if <50 kg) total post-op Clonidine (0.1mg) transdermal patch 0.05 mg/d folded in half and covered with patch	Gabapentin once pre-op / TID post-op	Gabapentin 1 hour pre-op / until discharge post-op Clonidine patch kept in place for 7 days post-op
Gettis32	Yes	15 mg/kg (maximum of 600 mg)	Once	30–60 minutes pre-op
Haddadi20	Yes	Gabapentin 10 mg/kg Acetaminophen 40 mg/kg suppository (after induction)	Once	Gabapentin 2 hours pre-op Acetaminophen – After induction
Mayell33	Yes	600 mg	Once	1 hour pre-op
Mohamed19	Yes	20 mg/kg	Once	2 hours pre-op
Pinto Filho31	Yes	10 mg/kg (maximum of 600 mg)	Once	1–2 hours pre-op
Rusy26	Yes	15 mg/kg pre-op / 5 mg/ kg post-op	Once pre-op / TID post-op	25–30 minutes pre-op / 5 days post-op
Salman40	Yes	15 mg/kg	Once	30 minutes pre-op
Thomas25	Yes	If >40kg, 300mg capsule pre- and post-op / If 20–40kg, 200 mg capsule pre- and post-op or 5 mg/kg pre- and post-op (if they could not swallow)	Once pre-op / TID post-op	Not stated pre-op / until discharge post-op
Tomaszek24	Yes	15 mg/kg pre-op / 7.5 mg/kg post-op	Once pre-op / BID post-op	1 hour pre-op / 3 days post-op
Trzcinski23	Yes	10 mg/kg pre-op / 5 mg/kg post-op	Once pre-op / TID post-op	Morning of surgery pre-op / 4 days post-op
Wang22	No	300 mg total	Once on Day 1, BID on Day 2, TID for Day 3 onward	30 days

TID, 3 times daily, BID, 2 times daily.