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Discontinued ADCs Classified by Payload Class. The major payload classes utilized in the discontinued ADCs are the microtubule inhibitors and DNA Damaging Agents. Topoisomerase I Inhibitors (Topo-1), targeted small molecules (SM), and undisclosed candidates combined make up ~9% of the discontinued ADCs. PBD, pyrrolobenzodiazepine; Cal., calicheamicin.
