Table 2.

Mendelian randomization analysis of biomarkers and delirium.

Phenotype	GWAS data source	P<5e-8, clumping at r2 = 0.001				P<5e-6, clumping at r2 = 0.001
		N	Range of F-statistic#	OR (95% CI)	P	N	Range of F-statistic#	OR (95% CI)	P
TNF-α	Suhre et al. (2017)	0	—	—	—	4	21.26–14.93	1.01 (0.83, 1.23)	0.90
CRP	Suhre et al. (2017)	0	—	—	—	2	22.25; 24.11	0.88 (0.68, 1.16)	0.37
	Sun et al. (2018)	4	39.38–52.26	0.86 (0.66, 1.12)	0.26	17	20.92–52.26	1.02 (0.86, 1.21)	0.80
IL-1α	Suhre et al. (2017)	1	31.36	0.85 (0.60, 1.22)	0.38	3	23.23–31.36	0.94 (0.76, 1.16)	0.55
	Sun et al. (2018)	0	—	—	—	19	20.86–26.15	1.02 (0.85, 1.21)	0.83
IL-1β	Suhre et al. (2017)	0	—	—	—	2	21.34; 22.13	0.90 (0.54, 1.51)	0.69
	Sun et al. (2018)	2	34.20; 99.20	1.09 (0.86, 1.37)	0.48	13	21.08–99.20	1.01 (0.86, 1.19)	0.86
IL-2	Suhre et al. (2017)	0	—	—	—	4	21.43–26.60	0.91(0.76, 1.01)	0.36
	Sun et al. (2018)	2	32.88; 60.36	0.99 (0.71, 1.39)	0.95	19	21.03–60.36	1.02 (0.89, 1.18)	0.57
IL-6	Sun et al. (2018)	0	—	—	—	15	20.82–27.20	0.39 (0.27, 0.56)	0.34
	Gilly et al. (2020)	0	—	—	—	14	21.40–27.72	1.03 (0.98, 1.09)	0.23
sIL-6Rα	Suhre et al. (2017)	1	2,377.54	0.89 (0.83, 0.96)	0.0016	3	21.09–2,377.54	0.91 (0.82, 1.01)	0.06
	Sun et al. (2018)	2	65.70; 1,588.92	0.89 (0.79, 0.96)	0.0045	15	20.85–1,588.92	0.94 (0.87, 1.02)	0.13
	Gilly et al. (2020)	2	60.19; 1,106.23	0.88 (0.80, 0.96)	0.0041	16	21.51–1,106.23	0.95 (0.88, 1.03)	0.26
Soluble gp130	Suhre et al. (2017)	1	64.63	1.19 (0.96, 1.47)	0.12	5	34.04–96.37	1.10 (0.95, 1.26)	0.20
	Sun et al. (2018)	4	34.04–96.37	0.98 (0.78, 1.22)	0.83	15	20.84–96.37	0.98 (0.84,1 .14)	0.78
IL-8	Suhre et al. (2017)	0	—	—	—	3	21.14–21.39	1.07 (0.89, 1.28)	0.49
	Sun et al. (2018)	0	—	—	—	17	21.06–28.80	1.06 (0.90, 1.24)	0.50

^#When less than 3 SNPs were available, all F-statistic values were shown; otherwise, the range of F-statistic range was reported.