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Incidence of renal tumours and karyomegaly in male F344/N rats (NTP, 1989)
| Dose in μg/kg bw per day | Adenomas | Carcinomas | Adenomas and carcinomas | Karyomegaly |
|---|---|---|---|---|
| 0 | 1/50 (2%) | 0/50 (0%) | 1/50 (2%) | 0/50 (0%) |
| 15 | 1/50 (2%) | 0/50 (0%) | 1/50 (2%) | 1/50 (2%) |
| 50 | 6/51 (12%) | 16/50 (31%) | 20/51 (39%) | 51/51 (100%) |
| 150 | 10/50 (20%) | 30/50 (60%) | 36/50 (78%) | 50/50 (100%) |
