Table 19.
Margins of exposure (MOE) values of the different age groups to the BMDL10 of 14.5 μg OTA/kg bw per day calculated from increased combined incidences of kidney tumours in male rats
| Age group | MOE calculated from mean dietary exposure | MOE calculated from P95 dietary exposure | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Minimum | Median | Maximum | Minimum | Median | Maximum | |||||||
| LB | UB | LB | UB | LB | UB | LB | UB | LB | UB | LB | UB | |
| Infants | 22,656 | 5,731 | 7,513 | 2,562 | 1,678 | 923 | 5,620 | 1,975 | 2,114 | 1,020 | 478 | 281 |
| Toddlers | 4,367 | 1,975 | 2,535 | 1,176 | 1,588 | 815 | 1,454 | 874 | 1,189 | 659 | 652 | 391 |
| Other children | 4,983 | 1,959 | 2,883 | 1,345 | 1,801 | 1,010 | 2,316 | 1,007 | 1,437 | 746 | 809 | 517 |
| Adolescents | 6,591 | 2,816 | 4,448 | 2,409 | 3,194 | 1,792 | 3,008 | 1,460 | 2,214 | 1,274 | 1,386 | 924 |
| Adults | 8,735 | 4,179 | 6,017 | 2,849 | 3,776 | 2,405 | 3,756 | 1,918 | 2,665 | 1,400 | 1,633 | 1,146 |
| Elderly | 11,154 | 4,693 | 7,005 | 3,194 | 4,062 | 2,346 | 4,589 | 2,171 | 3,372 | 1,684 | 1,686 | 1,058 |
| Very elderly | 13,182 | 5,534 | 6,971 | 3,208 | 4,039 | 2,726 | 6,042 | 2,827 | 3,652 | 1,716 | 2,778 | 1,578 |
| Pregnant women | 9,732 | 4,421 | 7,713 | 3,806 | 6,416 | 3,349 | 4,723 | 2,335 | 3,571 | 2,006 | 2,877 | 1,755 |
| Lactating women | 8,735 | 3,563 | 6,872 | 3,237 | 5,642 | 2,971 | 4,662 | 2,266 | 3,215 | 1,762 | 2,449 | 1,441 |
LB: lower bound; UB: upper bound; P95: 95th percentile.