Skip to main content
. 2023 Aug 10;19(8):e1011571. doi: 10.1371/journal.ppat.1011571

Fig 5. StcE treatment of human airway organoid-derived air-liquid interface cultures increases SARS-CoV-2 replication.

Fig 5

(A-D) Replication kinetics of SARS-CoV-2 in ALI cultures in terms of RNA copies (A, C) and infectious virus (B, D) in two donors. Represented values are the mean ± SD of three replicates. Statistical analysis was performed for donor 2 by repeated measures two way-ANOVA with Tukey’s post-hoc test. p<0.05 [*], p<0.01 [**], p<0.001 [***], p<0.0001 [****]. p<0.01 was found between NC and StcE and E447D and StcE treated cells at 1 day post infection and at 2 days post infection between E447D and StcE treated cells (C). p<0.05 was found between NC and StcE and E447D and StcE treated cells at 2 days post infection (D). (E-F) Microscopy images of untreated, 10ug/ml E447D or 10ug/ml StcE treated cells from donor 1 (E) or donor 2 (F), infected with SARS-CoV-2 at two days post-infection. White scale bars represent 100 μm. NP = nucleoprotein.