Table 2.
Outcomes in 1,396 Propensity Score-Matched Hospitalized Older Patients with Heart Failure (HF) with Reduced Ejection Fraction by Digoxin Discontinuation at Hospital Discharge
| Events (%) for digoxin discontinuation at hospital discharge |
Hazard ratio associated with digoxin discontinuation (95% CI); p value | ||
|---|---|---|---|
| No (n=698) | Yes (n=698) | ||
| 30-day outcomes | |||
| HF readmission | 89 (13%) | 101 (14%) | 1.19 (0.90–1.59); p=0.226 |
| All-cause readmission | 195 (28%) | 193 (28%) | 1.03 (0.84–1.26); p=0.778 |
| All-cause mortality | 47 (7%) | 82 (12%) | 1.80 (1.26–2.57); p=0.001 |
| HF readmission or all-cause mortality | 131 (19%) | 171 (24%) | 1.36 (1.09–1.71); p=0.007 |
| 6-month outcomes | |||
| HF readmission | 205 (29%) | 246 (35%) | 1.31 (1.08–1.57); p=0.005 |
| All-cause readmission | 377 (54%) | 409 (59%) | 1.18 (1.03–1.36); p=0.019 |
| All-cause mortality | 181 (26%) | 215 (31%) | 1.25 (1.02–1.52); p=0.028 |
| HF readmission or all-cause mortality | 321 (46%) | 377 (54%) | 1.28 (1.10–1.48); p=0.001 |
| 1-year outcomes | |||
| HF readmission | 276 (40%) | 317 (45%) | 1.28 (1.09–1.51); p=0.003 |
| All-cause readmission | 472 (68%) | 483 (69%) | 1.15 (1.02–1.31); p=0.028 |
| All-cause mortality | 251 (36%) | 287 (41%) | 1.21 (1.02–1.43); p=0.028 |
| HF readmission or all-cause mortality | 415 (59%) | 475 (68%) | 1.27 (1.11–1.45); p<0.001 |
| 4-year outcomes | |||
| HF readmission | 391 (56%) | 407 (58%) | 1.21 (1.05–1.39); p=0.007 |
| All-cause readmission | 595 (85%) | 579 (83%) | 1.16 (1.04–1.31); p=0.010 |
| All-cause mortality | 498 (71%) | 510 (73%) | 1.09 (0.97–1.24); p=0.163 |
| HF readmission or all-cause mortality | 607 (87%) | 624 (89%) | 1.20 (1.07–1.34); p=0.002 |