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. Author manuscript; available in PMC: 2023 Aug 29.
Published in final edited form as: NEJM Evid. 2022 Sep 13;1(10):10.1056/evidoa2200091. doi: 10.1056/evidoa2200091

Figure 3. Forest Plot of Participant-Level Meta-Analysis.

Figure 3.

Forest plot of our participant-level (PL) meta-analysis assessing the relationship between (Panels A and B) endotrophin and death and (Panels C and D) death or heart failure–related hospital admission in six heart failure (HF) with preserved ejection fraction cohort studies in unadjusted analyses (Panels A and C) and models adjusted for MAGGIC (Meta-Analysis Global Group in Chronic Heart Failure) risk score (Panels B and D). A hazard ratio >1 indicates a higher risk of death with higher endotrophin levels. PEOPLE denotes, Prospective Evaluation of Outcome in Patients with Heart Failure with Preserved Left Ventricular Ejection Fraction; TOPCAT, Treatment of Preserved Cardiac Function HF with an Aldosterone Antagonist trial.