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. 2023 Aug 9;12:e83981. doi: 10.7554/eLife.83981

Figure 2. CD8+ Trm in oral lichen planus (OLP) patients have different transcriptomic landscapes in different clinical presentations.

(A) Uniform manifold approximation and projection (UMAP) plot of NK/T cells colored by subtype. (B) Dot plot of marker genes in NK/T cells subsets. (C) Proportion of NK/T cell subsets in OLP with different clinical manifestations. (D) Dot plot of significant differentially expressed genes (DEGs) in NK/T cells subsets. (E) Dot plot of differential expression of inflammatory cytokine product genes in NK/T cell subsets. (F) Dot plot of GO enrichment analysis of DEGs between erosive oral lichen planus (EOLP) and non-erosive oral lichen planus (NEOLP). (G) Pseudotime trajectory of NA/T cells in OLP.

Figure 2—source code 1. Comprehensive analysis of NK/T cell in OLP samples: UMAP visualization, cell typing, marker genes, DEGs, inflammatory cytokine profiles, GO enrichment analysis, and pseudotime trajectory between EOLP and NEOLP.
Figure 2—source data 1. Percentage of NK/T cell subsets in EOLP and NEOLP.

Figure 2.

Figure 2—figure supplement 1. Transcriptional Profiling of NK/T Cells in OLP.

Figure 2—figure supplement 1.

(A) Transcription atlas of NK/T cells clustering in each oral lichen planus (OLP) sample. (B) Heatmap of differentially expressed genes per cluster in NK/T cells. (C) Heatmap of expressed genes for each cell subpopulation in NK/T cells.
Figure 2—figure supplement 1—source code 1. Transcriptional Profiling of NK/T Cells in OLP: Clustering, DEGs, and Cell Subpopulation Expression.
Figure 2—figure supplement 2. Analysis of differentially expressed genes (DEGs) in oral lichen planus (OLPs).

Figure 2—figure supplement 2.

(A) The differential gene violin plot for erosive oral lichen planus (EOLP)/non-erosive oral lichen planus (NEOLP) with statistical significance. (B) The differential gene violin plot for CD8+ Trm cluster in EOLP/ NEOLP with statistical significance.