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. 2023 Aug 18;13(13):4574–4600. doi: 10.7150/thno.86928

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Association of immune characteristics with the HDS. (A) The correlation between the HDS and TME cell enrichment scores was analyzed in five gastric cancer cohorts. (B) The HDS was significantly negatively correlated with the expression of angiogenic molecules in five gastric cancer cohorts. (C) Flow chart of RNA-seq. (D) Survival analysis revealed that patients with a high HDS had longer OS and DFS. (E) The correlation between the HDS and TME cell enrichment scores was analyzed in the PKUPH cohort. (F) The expression levels of CD8 and PD-L1 proteins in high- and low-HDS samples.