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. 2023 Aug 15;13(13):4512–4525. doi: 10.7150/thno.85946

Figure 6.

Figure 6

Incorporating aspirin in mTCP-μRB scaffolds enhanced MSC osteogenesis in vivo and in vitro in a dosage-dependent manner. (A-B) Representative immunostaining images (A) and quantification (B) of OCN+ MSC in the cranial defect treated with 0/10/20 μg Asp-loaded mTCP-μRB scaffolds at week 2. (n = 3/group) (C-D) Representative immunostaining images of OCN+ area (C) and quantification (D) on the mTCP-μRB scaffolds treated with varying concentrations of Asp in vitro at day 7. (E) Normalized gene expression of MSC osteogenic markers in vitro at day 7. (n = 4/group). Scale bar in (A, C): 100 μm. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.