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. 2023 Aug 6;13(13):4449–4468. doi: 10.7150/thno.84710

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Evaluation of cross-reaction with peptides from MAGE-A12 and Titin by candidate TCRs. (A) Summary of the predicted top 5 HLA-A2 restricted T cell epitopes from MEGA-12 and Titin protein. (B) Heatmap visualization of the docking prediction results between the 5 candidate TCRs and HLA-A2 presenting distinct epitopes. Color intensity represents different docking stability score, with darker colors indicating higher score and suggesting more stable pMHC-TCR complex. (C) The simulated pMHC-TCR complex docking structure of the 5 candidate TCR with MAGE-A3-Mp4: the top part is the structure of TCR and the bottom is the structure of HLA-A2 presenting the MAGE-A3-Mp4 peptide.