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. 2023 May 22;55(9):836–846. doi: 10.1055/a-2038-0541

Table 2. Univariate Cox proportional hazards models for progression to an advanced lesion in the pouch body and cuff, with risk factors at year 10 (landmark time-point analysis).

Variable Pouch body Cuff
Number (n = 165) Adjusted hazard ratio (95 %CI) P value 1 Number (n = 158) Adjusted hazard ratio (95 %CI) P value 2
Female sex 76 0.7 (0.4–1.4) 0.34 71 0.7 (0.4–1.6) 0.42
Age at pouch surgery, years 1.01 (0.98–1.05) 0.53 1.0 (0.97–1.04) 0.72
APC pathogenic variant type

  • 1250–1450 (MCR)

 48 1 ref 46 1 ref

  • 1–1249

 99 1.2 (0.5–2.7) 0.64 95 1.4 (0.5–3.5) 0.50

  • > 1450

 12 3.2 (0.8–12.4) 0.09 11 4.6 (1.3–16.7) 0.02

  • Gross deletion

 6 –  > 0.99 6 2.1 (0.4–10.5) 0.37
Type of initial pouch surgery

  • IRA (secondary RPC)

 59 1 ref 58 1 ref

  • Primary RPC

 106 1.09 (0.5–2.3) 0.81 100 1.5 (0.7–3.4) 0.33
Type of anastomosis 3

  • Handsewn

 60 1 ref

  • Stapled

 30 3.8 (1.2–11.9) 0.02
Adenoma number (at most recent examination where number was recorded before year 10) 4

  • None

 63 1 ref 73 1 ref

  • 1 or more

 41 4.8 (1.6–14.1) 0.004 24 6.8 (2.5–18.3)  < 0.001
Adenoma size (at most recent examination where size was recorded before year 10), mm 5

  • None

 62 1 ref 30 1 ref

  • 1–4

 36 5.8 (1.7–20.4) 0.005 12 3.1 (0.97–9.85) 0.06

  • 5–9

 6 32.4 (5.8–177.1)  < 0.001 1 – –

MCR, mutation cluster region; IRA, ileorectal anastomosis; RPC, restorative proctocolectomy.

1

Progression to an advanced lesion in the pouch body (32/165). Statistical significance in univariate analyses indicated when P  < 0.01. This pragmatic approach led to the same variables being considered statistically significant as in the stricter approach requiring P  < 0.008 with Bonferroni multiple testing correction for six potential variables (shown in bold).

2

Progression to an advanced lesion in the cuff (29/158). Statistical significance in univariate analyses indicated when P  < 0.01. This pragmatic approach led to the same variables being considered statistically significant as in the stricter approach requiring P  < 0.007 with Bonferroni multiple testing correction for seven potential variables (shown in bold).

3

Cuff group, n = 90.

4

Pouch body, n = 104 with 16 advanced lesions; cuff, n = 97, with 17 advanced lesions.

5

Pouch body, n = 104, with 16 advanced lesions; cuff, n = 43, with 13 advanced lesions.