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The general mechanism underlying immune system response to SARS-CoV-2 invasion. When the PAMP of the virus attaches to the PRR, the pattern of the virus is detected by immune system. This leads to a signal transduction to the genome of immune cells and as a result, it can activate the cytokine genes. Activation of cytokine genes lead to cytokine release. If the cytokine release happens excessively, the cytokine storm happens.
