Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Aug 15;14:1238647. doi: 10.3389/fimmu.2023.1238647

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Jiang, Jiang, Chen and He

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Role of platelet activation in psoriasis and cardiovascular disease. (i) Activated platelets interact with leukocytes through CD40-CD40L or P-selectin-PSGL-1 cross-talk and facilitate leukocyte migration, leading to skin infiltration and thromboinflammatory injury. (ii) Platelets contribute to activation of immune cells and increased release of NETs from PMNs, cytokines from DCs, Th17 cells and neutrophils, and MMPs from macrophages, further promoting thrombosis and plaque rupture. (iii) Platelet activation induces secretion of cytokines and adhesion molecules by endothelial cells, resulting in endothelial dysfunction. In summary, activated platelets work as promoters for psoriasis and psoriasis-associated CVD. CD40L, CD40 ligand; PSGL-1, P-selectin glycoprotein ligand-1; NET, neutrophil extracellular trap; PMN, polymorphonuclear neutrophil; DC, dendritic cell; EC, endothelial cell; MΦ, macrophage.