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. 2023 Aug 29;13:14158. doi: 10.1038/s41598-023-40638-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The evolution of the dural substitute (and corresponding 3D renderings). (A) PDMS with silicone straps worked well but prevented later cortical impact. (B) PDMS with “top hat” portion to fill the edges of the burr hole. This version was difficult to place without causing cortical trauma. (C) PDMS with flat silicone ring. The ring didn’t provide much advantage and limited the area for 2P imaging. (D) Flat PDMS with ridges to identify the center of the PDMS. This iteration was relatively easy to install, allowed centering of the PDMS, and could withstand injections and cortical impact.