Table 4.
Association between exposure to SARS-CoV-2 during pregnancy exposure period and maternal outcomes, calculated using conditional logistic regression
| Cohort (Outcome) | Infection status | Number of pregnancies/ neonates | Number with outcome | % with outcome | Odds ratio accounting for only matchinga [95% CI] | P valuea | Adjusted odds ratiob [95% CI] | P valueb |
|---|---|---|---|---|---|---|---|---|
| 7 (Critical care and/or Death) | Infected | 4074 | 175 | 4.3% | 1.83 [1.51-2.21] | <0.001 | 1.72 [1.39-2.12] | <0.001 |
| Uninfected | 12222 | 290 | 2.4% | Ref | – | Ref | – | |
| 8 (Venous thromboembolism) | Infected | 4072 | 29 | 0.7% | 2.72 [1.65–4.49] | <0.001 | 2.53 [1.47–4.35] | <0.001 |
| Uninfected | 12216 | 32 | 0.3% | Ref | – | Ref | – | |
| 9 (Hypertensive disorders of pregnancy) | Infected | 4071 | 178 | 4.4% | 0.85 [0.72-1.01] | 0.06 | 0.82 [0.68-0.98] | 0.03 |
| Uninfected | 12213 | 624 | 5.1% | Ref | – | Ref | – | |
| 10 (Pregnancy-related bleeding) | Infected | 3973 | 1665 | 41.9% | 0.96 [0.90-1.05] | 0.33 | 0.97 [0.90-1.04] | 0.39 |
| Uninfected | 11919 | 5101 | 42.8% | Ref | – | Ref | – |
CI confidence interval
aMatched for maternal age, gestation at infection/matching and seasons of conception and additionally for health board of residence (Greater Glasgow & Clyde or Lanarkshire versus all other health boards) for hypertensive disorders of pregnancy and pregnancy-related bleeding.
bAdjustment for parity and deprivation only for analyses with the following outcomes: venous thromboembolism. Adjustment for all covariates for analyses for the following outcomes: maternal critical care or death, hypertensive disorders of pregnancy and pregnancy-related bleeding.