Table 2.

Odds ratios and 95% confidence intervals for the osteoporosis according to the systemic immune‐inflammation index levels.

SII	Osteoporosis, n	Prevalence, %	Univariate model	Model 1	Model 2	Model 3	Model 4
Categorical
Tertile 1 (≤500)	188/2237	8.40	1 (Ref.)	1 (Ref.)	1 (Ref.)	1 (Ref.)	1 (Ref.)
Tertile 2 (>500, ≤1000)	190/1912	9.94	1.233 (0.900–1.689)	1.081 (0.761–1.513)	1.216 (0.887–1.667)	1.259 (0.915–1.723)	1.239 (0.903–1.712)
Tertile 3 (>1000)	57/476	11.97	1.483 (1.083–2.030)	1.313 (0.928–1.849)	1.455 (1.062–1.994)	1.509 (1.117–2.089)	1.485 (1.097–2.057)
P for trend		<0.001	<0.001	<0.001	0.037	0.028	0.035

Note: Model 1 adjust for the covariates of age, gender and physical activity level; Model 2 adjust for the covariates of diabetes, hypertension and family history of osteoporosis; Model 3 adjust for the covariates of smoking, drinking alcohol, renal function and 25(OH)D status; Model 4 is a fully‐adjusted model; SII, systemic immune‐inflammation index; 25(OH)D, 25‐hydroxyvitamin D.