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. 2023 May 15;13(8):3365–3381. doi: 10.1016/j.apsb.2023.05.010

Figure 2.

Figure 2

Pharmacological inhibition of PIEZO2 MA channel activity suppressed VCR-induced mechanical hypersensitivity. Mechanical allodynia (A) and mechanical hyperalgesia (D) were elicited by VCR administration (i.p., 50 μg/kg/day) following the schedule (above). At the 9th day of VCR administration, mechanical withdrawal thresholds (B) and nociceptive withdrawal thresholds (E) were tested before (baseline, BL) and at 30, 60 and 90 min after intraplantar injection (arrow at 0 min) of GdCl3 (300 μmol/L, 100 μL) (triangle) or the same volume of vehicle (circle). A group of rats was considered as negative control (square). At the 11th day of VCR administration, mechanical withdrawal thresholds (C) and nociceptive withdrawal thresholds (F) were tested before (baseline, BL) and at 30, 60 and 90 min after intraplantar injection (arrow at 0 min) of CD (1 mmol/L, 100 μL) (triangle) or the same volume of vehicle (circle). A group of rats was considered as negative control (square). Data are shown in mean ± SEM, n = 8 each group; ∗/#P < 0.05, ∗∗/##P < 0.01, ∗∗∗P < 0.001.