Table 1. Baseline Characteristics of the Study Population, Explicit Sepsis ICD-10 Group, and Sepsis-3 Reference Standard Subgroupa.
| Factor | Patients, % (95% CI) | ||
|---|---|---|---|
| Sample population (N = 997) | Sepsis-ICD-10 subgroup (n = 315) | Sepsis-3 Subgroup (n = 457) | |
| Age, median (IQR), y | 71 (60-82) | 75 (64-86) | 76 (67-85) |
| Sex | |||
| Female | 46.5 (38.1-55.0) | 39.6 (31.2-48.7) | 50.8 (43.3-58.3) |
| Male | 53.5 (49.1-58.3) | 60.3 (51.7-68.9) | 49.2 (42.8-55.7) |
| Admitted from nursing home | 6.8 (3.6-12.3) | 9.5 (5.4-16.1) | 13.6 (9.2-19.6) |
| Discharged to nursing home | 7.8 (4.4-13.6) | 6.9 (3.4-13.5) | 14.0 (9.3-20.7) |
| Intermediate care | 17.0 (11.6-24.3) | 23.8 (16.9-32.3) | 27.7 (21.4-34.9) |
| Intensive care | 5.6 (2.8-10.8) | 20.9 (15.1-28.2) | 15.6 (11.5-20.8) |
| Length of stay, median (IQR), d | 3 (2-6) | 9 (4-15) | 6 (2-11) |
| Comorbidities | |||
| Myocardial infarction | 10.2 (6.2-16.3) | 11.6 (7.0-18.5) | 19.2 (13.9-25.9) |
| Peripheral vascular disease | 2.6 (1.1-6.6) | 6.9 (3.5-13.0) | 6.6 (3.8-11.3) |
| Congestive heart failure | 4.7 (2.4-8.7) | 13.8 (8.7-21.1) | 17.1 (12.1-23.6) |
| Mild diabetes | 14.9 (9.9-22.0) | 23.5 (16.7-32.1) | 25.1 (19.0-32.4) |
| Severe diabetes | 0.6 (0.4-1.0) | 5.4 (2.5-11.3) | 4.7 (2.5-8.8) |
| Mild liver disease | 1.1 (0.2-5.2) | 2.2 (0.7-7.1) | 2.4 (0.9-6.5) |
| Severe liver disease | 0.2 (0.1-0.4) | 0.2 (0.1-0.5) | 0.6 (0.1-2.6) |
| Chronic obstructive pulmonary disease | 6.3 (3.4-11.3) | 11.0 (6.5-18.0) | 15.2 (10.5-21.5) |
| Chronic kidney disease stage 5 | 1.5 (0.5-4.7) | 6.6 (3.3-13.0) | 5.8 (3.2-10.4) |
| Connective tissue disease | 3.2 (1.3-7.9) | 7.6 (3.9-14.0) | 9.0 (5.4-14.7) |
| Peptic ulcer disease | 1.3 (0.3-4.8) | 5.5 (2.6-11.4) | 2.4 (1.2-4.7) |
| Cerebrovascular accident | 11.2 (6.9-17.5) | 20.9 (14.3-29.4) | 20.3 (15.0-26.9) |
| Hemiplegia | 1.3 (0.4-4.8) | 4.1 (1.7-9.9) | 2.9 (1.4-6.1) |
| Dementia | 6.1 (3.1-11.8) | 4.5 (1.9-10.0) | 9.7 (6.1-15.0) |
| Solid tumor | 11.8 (7.3-18.4) | 16.9 (11.0-24.9) | 14.0 (9.5-20.2) |
| Metastasis | 4.6 (1.8-11.3) | 6.6 (3.1-13.4) | 10.5 (6.0-17.9) |
| No comorbidities | 51.8 (43.3-60.2) | 25.3 (18.3-33.9) | 21.8 (16.1-28.8) |
Abbreviation: ICD-10, International Statistical Classification of Diseases and Related Health Problems, Tenth Revision.
a
The weighted baseline demographic characteristics of the study sample population, sepsis-3 categorized subgroup, and explicit sepsis ICD-10-subgroup (A- and R-sepsis).