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. Author manuscript; available in PMC: 2023 Aug 30.
Published in final edited form as: Behav Brain Res. 2019 Nov 22;379:112379. doi: 10.1016/j.bbr.2019.112379

Figure 1.

Figure 1.

Anxiety-like behavior following administration of KOR activation assessed on the EPM in male and female adolescents (left) and adults (right). Animals were given an i.p. injection of KOR agonist U69593 (0.01, 0.1, or 1 mg/kg) or vehicle, and anxiety-like behaviors were tested 20 min following injection. There was a significant overall difference between adults and adolescents (not indicated). (A, B) Percent time spent in the open arms; (C, D) total number of open arm entries. Open gray circles are used to identify statistical outliers that have been removed from analysis. * - p = 0.05 compared to vehicle.