Table 1.

Proposed Mayo Clinic Diagnostic Criteria for Lupus Pernio.

Major Criteria Localized erythema and swelling involving acral sites and persistent for >24 h

Minor Criteria Onset and/or worsening in cooler months (between November and March) Histopathologic findings of skin biopsy consistent with pernio (eg, dermal oedema with superficial and deep perivascular lymphocytic infiltrate) and without findings of lupus erythematosus Response to conservative treatments (ie, warming and drying of affected areas)

Diagnosis requires major criterion and at least one of the minor criteria to be fulfilled