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. Author manuscript; available in PMC: 2023 Aug 30.
Published in final edited form as: Sci Transl Med. 2022 Aug 17;14(658):eabq4130. doi: 10.1126/scitranslmed.abq4130

Fig. 5. Memory B cell responses are induced by AS03-adjuvanted RBD-nanoparticle vaccination.

Fig. 5.

(A) Representative flow cytometry profile shows ancestral Spike protein–specific B cell frequencies gated as live, CD20+ IgD− IgM− Spike+ cells. The insets show proportion of Wu Spike+ cells that bind to Omicron versus Beta probes. A higher number of events is shown in the insets to improve visibility. SSC-A, Side Scatter-Area. (B) Frequency of Spike protein–specific memory B cells relative to CD20+ B cells is shown for samples from the RBD-Wu/RBD-Wu/RBD-Wu (top), RBD-Wu/RBD-Wu/RBD-β (blue, bottom), and HexaPro/HexaPro/RBD-β groups (red, bottom) groups. (C) Donut charts showing proportion of Spike protein–specific memory B cells bound to ancestral (WT), Omicron, and Beta probes, as indicated in the legend.