Table 2.
Evaluation of cytotoxicity of purified pyocyanin from PsC05 and PsE02 isolates
| In vitro Cytotoxicity (IC50 µg/ml) * | |||||||
|---|---|---|---|---|---|---|---|
| HePG2 | HCT-116 | Hela | MCF-7 | PC3 | WI38 | WISH | |
| DOX** | 4.50 ± 0.2 | 5.23 ± 0.3 | 5.57 ± 0.4 | 4.17 ± 0.2 | 8.87 ± 0.6 | 6.72 ± 0.5 | 3.34 ± 0.2 |
| PsE02 | 61.71 ± 3.4 | 53.06 ± 3.1 | 74.13 ± 3.9 | 37.29 ± 2.2 | 63.21 ± 3.3 | 85.47 ± 4.1 | > 100 |
| PsC05 | 46.45 ± 2.7 | 32.34 ± 2.1 | 39.27 ± 2.3 | 28.85 ± 1.9 | 41.31 ± 2.3 | 92.23 ± 4.5 | > 100 |
* IC50 (µg/ml): 1–10 (very strong), 11–20 (strong), 21–50 (moderate), 51–100 (weak), and above 100 (non-cytotoxic)
** DOX: Doxorubicin