Table 2.
Metabolic indexes, ovarian function and ART outcomes of two study groups
| Characteristics | Endometriosis (n = 412) |
Controls (n = 1551) |
P value |
|---|---|---|---|
| Basal E2 (pmol/L) | 114.65 (67.97–156.58) | 110.70 (67.70–153.60) | 0.405 |
| Basal P (nmol/L) | 1.14 (0.75–1.55) | 1.12 (0.76–1.50) | 0.644 |
| Basal T (nmol/L) | 0.50 (0.00–0.80) | 0.60 (0.00–0.90) | 0.005 |
| Glu (mmol/L) | 5.01 (4.79–5.27) | 5.04 (4.80–5.31) | 0.134 |
| INS (μU/mL) | 6.90 (5.10–9.50) | 6.50 (4.80–8.90) | 0.005 |
| TG (mmol/L) | 0.92 (0.71–1.19) | 0.92 (0.69–1.27) | 0.435 |
| TC (mmol/L) | 4.35 (3.92–4.80) | 4.27 (3.81–4.77) | 0.036 |
| HDL-C (mmol/L) | 1.36 (1.19–1.57) | 1.32 (1.14–1.52) | 0.005 |
| LDL-C (mmol/L) | 2.63 (2.17–3.01) | 2.54 (2.12–2.94) | 0.043 |
| TP (g/L) | 71.97 ± 4.49 | 72.20 ± 4.77 | 0.318 |
| ALT (U/L) | 13.00 (10.00–17.00) | 13.00 (10.00–18.00) | 0.178 |
| AST (U/L) | 17.00 (15.00–20.00) | 18.00 (15.00–20.00) | 0.068 |
| Creatinine (μmoI/L) | 56.00 (50.00–62.60) | 55.10 (49.00–62.00) | 0.202 |
| Urea nitrogen (mmol/L) | 3.78 (3.21–4.48) | 3.76 (3.18–4.51) | 0.621 |
| Uric acid (μmoI/L) | 266.00 (234.25–303.00) | 270.00 (231.00–312.00) | 0.277 |
| HCY (nmol/L) | 9.70 (8.50–10.80) | 9.80 (8.50–11.10) | 0.281 |
| AMH (ng/mL) | 2.02 (1.06–3.49) | 2.53 (1.48–4.07) | < 0.001 |
| AFC (n) | 8.00 (5.00–11.00) | 10.00 (7.00–12.00) | < 0.001 |
| Basal FSH (IU/L) | 6.74 (5.26–8.35) | 6.32 (4.81–7.87) | < 0.001 |
| Basal LH (IU/L) | 4.19 ± 2.40 | 4.60 ± 2.66 | 0.031 |
| Gn dosage (IU) | 2025.00 (1575.00–2700.00) | 2025.00 (1575.00–2475.00) | 0.664 |
| Gn days (day) | 9.00 (8.00–12.00) | 9.00 (8.00–11.00) | 0.058 |
| Number of retrieved oocytes (n) | 7.00 (4.00–11.00) | 9.00 (5.00–14.00) | < 0.001 |
| Fertilization rate [%] | 64.3 (2158/3357) | 64.0 (9714/15172) | 0.778 |
| Cleavage rate [%] | 23.7 (512/2158) | 24.1 (2338/9714) | 0.736 |
| Number of transferable embryos (n) | 0.76 ± 0.93 | 0.77 ± 0.93 | 0.776 |
| Number of high-quality embryos (n) | 0.57 ± 0.82 | 0.60 ± 0.83 | 0.402 |
| High-quality embryos rate [%] | 12.1 (232/1912) | 11.1 (936/8435) | 0.196 |
| Number of embryos transferred (n) | 1.81 ± 0.39 | 1.78 ± 0.41 | 0.389 |
| Implantation rate1 [%] | 38.7 (122/315) | 36.0 (429/1191) | 0.375 |
| Ectopic pregnancy rate2 [%] | 2.3 (4/174) | 1.5 (10/669) | 0.684 |
| Clinical pregnancy rate3 [%] | 51.7 (90/174) | 49.5 (331/669) | 0.597 |
| Miscarriage rate4 [%] | 6.9 (12/174) | 5.7 (38/669) | 0.606 |
| Delivery rate5 [%] | 45.4 (79/174) | 43.8 (293/669) | 0.606 |
| Live birth rate6 [%] | 54.0 (94/174) | 54.0 (361/669) | 0.988 |
Values are expressed as mean ± standard deviation, median (interquartile range) or number (%)
E2 estradiol, P progesterone, T testosterone, Glu glucose, INS insulin, TG triglycerides, TC total cholesterol, HDL-C high density lipoprotein cholesterol, LDL-C low density lipoprotein cholesterol, TP total protein, ALT alanine aminotransferase, AST aspartate aminotransferase, HCY homocysteine, AMH anti-Müllerian hormone, AFC antral follicle counting, FSH follicle stimulating hormone, LH luteinizing hormone, Gn gonadotropin. 1. Implantation rate: the ratio of the number of gestational sacs to the total number of embryos transferred. 2. Ectopic pregnancy rate: the ratio of the number of Ectopic pregnancy cycles to the total number of transfer cycles. 3. Clinical pregnancy rate: the ratio of the number of clinical pregnancy cycles to the total number of transfer cycles. 4. Miscarriage rate: the ratio of the number of miscarriage cycles to the total number of transfer cycles. 5. Delivery rate: the ratio of the number of deliveries that resulted in at least one live born baby to the total number of transfer cycles. 6. Live birth rate: the ratio of the number of live born babies to the total number of live born babies