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. 2023 Aug 16;10:1211888. doi: 10.3389/fmed.2023.1211888

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Copyright © 2023 Su, Zhang, Zhou, Zhang, Chen, Zhang, Wang, Zhang, Zhang, Li, Zhang, Wang, Yuan, Zhang, Zhou, Cao, Zhang and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comprehensive analysis of important genes and their functions in non-HPV-associated cervical cancer. (A) Sample dendrogram showing the correlation between sample characteristics and HPV infection; red bars are non-HPV-infected CESCs. (B) Nineteen genes that are highly associated with non-HPV infection and mutated in patients. The abscissa indicates the correlation with non-HPV, and a high correlation is a positive value. Colors represent p-values. (C) Mutation ratios in COSMIC of six genes associated with non-HPV-infected CESC, normalized by z score. (D) GSEA enrichment analysis yielded six downregulated pathways with the lowest enrichment scores. (E) High expression of ALKBH7 was associated with better prognosis and survival (top), whereas high expression of MYCBP was associated with worse prognosis and survival (bottom).