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. 2023 Jun 22;33(5):e13182. doi: 10.1111/bpa.13182

FIGURE 6.

FIGURE 6

Imaging and histopathological features of gangliogliomas. (A–D) MR images of case #10, showing a left internal temporal mass with tissular content. The mass has microcalcifications on CT (A), low signal on T2‐weighted images (B), faint contrast enhancement (C), restricted diffusion on ADC map (D), and intermediate cerebral blood flow using ASL (75 mL/min/100 g) (E). (F) Diffuse glial proliferation with calcifications (case #10, HPS, magnification 400×). (G) Diffuse growth pattern using neurofilament staining (case #10, magnification 400×). (H) MIB1 labeling index (case #10, magnification 400×). (I–M) MR images of case #12, showing a left internal temporal mass with tissular content. The mass has heterogeneous low signal on T2‐weighted images (I), hyperintense signal on T1‐weighted images pre‐contrast (J), weak contrast enhancement (K), restricted diffusion on ADC map (L), and intermediate cerebral blood flow using ASL (56 mL/min/100 g) (M). (N) Diffuse glial proliferation with calcifications and oligodendroglial‐like features (case #11, HPS, magnification 400×). (O) Diffuse growth pattern using neurofilament staining (case #11, magnification 400×). (P) Diffuse and strong expression of FGFR3 (case #11, magnification 400×). (Q) CD34 extravascular expression (case #11, magnification 400×). (R) Diffuse and strong expression of FGFR3 (case #11, magnification 400×). Black scale bars represent 50 μm. ADC, diffusion coefficient map; ASL, arterial spin labeling; HPS, hematoxylin–phloxin–saffron; MR, magnetic resonance.