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. 2023 Jun 18;33(5):e13180. doi: 10.1111/bpa.13180

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© 2023 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf of International Society of Neuropathology.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Synaptic and glial responses against injury. Representative scheme of neuronal and glial responses against pathology in the amygdala according to proteomic data analysis and the literature. Reductions in ADAP1 and CEND1 suggest synaptic dysfunction. To control the disease, ANXA2 might mediate autophagosome‐lysosome fusion. Astrocytes might promote the activation of phagocytic microglia (PRDX6) and mark neurons for their clearance by microglia (ANXA1). Microglia might have a dual role since protective (ANXA5) and neurotoxic (CLIC1) roles have been linked. Created with BioRender.com