TABLE 3.
Identified proteins from DEPs that interact with pathological proteins and expressed in neurons, microglia, and astrocytes.
| DEPs‐neurons | DEPs‐neurons‐Aβ | DEPs‐neurons‐tau | DEPs‐neurons‐Aβ‐tau |
|---|---|---|---|
| CEND1, WDR47, DIRAS2 | ‐ | ‐ | ‐ |
| DEPs‐microglia | DEPs‐Microglia‐Aβ | DEPs‐Microglia‐Tau | DEPs‐Microglia‐Aβ‐Tau |
|---|---|---|---|
| PLD3, ANXA1, COTL1, S100A11, CLIC1, SERPINA3, MSN, ANXA11, CAPG, LCP1, GALM, PPT1, ISYNA1, CSTB, HEXA, AIF1, SORD, SH3KBP1 | PSME2, LGALS3BP | ‐ | ANXA5 |
| DEPs‐astrocytes | DEPs‐Astrocytes‐Aβ | DEPs‐Astrocytes‐Tau | DEPs‐Astrocytes‐Aβ‐Tau |
|---|---|---|---|
| F3, NEBL, CBR3, AHCYL2, NES, CNN3, AGLN, CMBL, PBXIP1, MRAS, DAG1, ITGA7, MAP4, FOLH1, AMER2, PHYHIPL, LGALSL, TJP2 | FLOT2 | PRDX6 | CLU |
Note: Four main groups are presented: proteins preferentially expressed in cell type, proteins preferentially expressed in cell type that interact with Aβ, proteins preferentially expressed in cell type that interact with tau, and proteins preferentially expressed that interact with both markers are shown.