TABLE 1.

Summary of histopathologic and clinical features of TRAK1::RAF1 fusion positive pediatric low grade glial‐glioneuronal tumors

	Age at Diagnosis	Sex	Presenting symptoms	Tumor Location	Surgery*	Tumor Ki‐67 proliferative index	Tumor Mitoses	Histopathologic Diagnosis*	v12.5 Methylation Class (Score)	Fusion	Additional tumor cytogenetic and molecular features	Recurrence/progression	Follow‐up (months)
Case 1	8 years	Female	Seizure	Left frontal cortex	GTR	elevated (5‐10%)	Rare	LGG/LGNT, NOS	Pilocytic astrocytoma, hemispheric ( 0.6)	TRAK1::RAF1	broad loss of Chromosome 3p	focal recurrent tumor noted on 14 month surveillance MRI; treated by complete re‐resection (NED at 5 month follow‐up)	19
Case 2	9 months	Female	Decreased motor activity (arm/leg)	Left fronto‐parietal leptomeninges	GTR	low (< 5%)	Absent	DIG	Desmoplastic infantile ganglioglioma / desmoplastic infantile astrocytoma (1.0 )	TRAK1::RAF1	(none detected; germline Chr 15p deletion)	none	53
Case 3	15 months	Female	Seizure	Right parietal/occipital leptomeninges	STR	elevated (>10%)	Rare	DLGNT	Desmoplastic infantile ganglioglioma / desmoplastic infantile astrocytoma (1.0 )	TRAK1::RAF1	(none detected)	none	15

*Abbreviations: DLGNT = diffuse leptomeningeal glioneuronal tumor; GTR = gross total resection; LGG‐LGNT, NOS = low grade glial‐glioneuronal tumor, not other specified; NED = no evidence of disease; STR+ subtotal resection.