Figure 8.

miR-155-5p regulates fibrosis by the activation of TGF-β/Smad2/3 pathway. Smad2/3 levels were analyzed by Western blotting (a) in vivo and (b) in vitro. The levels of Smad2/3 in cytosol and nuclear after miR-155-5p inhibition were analyzed in (c). Data represent the mean ± S.D. of experiments with 6 mouse colon tissues per group (in vivo) and 3 experiments with triplicate samples (in vitro), and significance was determined by comparing with the control using Duncan’s studentized range test (in vivo) and Tukey’s studentized range test (in vitro); different letters mean significant differences at p < 0.05.