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. 2023 Aug 29;14:20417314231186918. doi: 10.1177/20417314231186918

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© The Author(s) 2023

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — Extracellular vesicles (EVs) from mechanically activated osteoblasts and osteocytes influence HUVEC proliferation and migration. (a) Quantification of HUVEC number after 24 h cultured in fresh medium without VEGF (negative control), with VEGF (positive control), mechanically activated MC3T3-E1 CM depleted of EVs (OsB_MA-CM_woEV) or isolated EVs (OsB_MA-EV), and mechanically activated MLO-Y4 CM depleted of EVs (OsY_MA-CM_woEV) or isolated EVs (OsY_MA-EV). (b) Quantification of HUVECs migrated through a porous membrane in fresh medium without VEGF (negative control), with VEGF (positive control), mechanically activated MC3T3-E1 CM depleted of EVs (OsB_MA-CM_woEV) or isolated EVs (OsB_MA-EV), and mechanically activated MLO-Y4 CM depleted of EVs (OsY_MA-CM_woEV) or isolated EVs (OsY_MA-EV). Data presented as Mean ± SD, N = 3–7. *p < 0.05 VS wo VEGF, ^#p < 0.05 VS MA-CM_woEV, and p < 0.05 VS MA-EV.