FIGURE 1.
Immunopathogenesis of AD. Acute and chronic stages of AD and selected T-cell subpopulations and interleukins, other inflammatory cytokines and IgE antibodies, and selected cell populations ILC2, APCs, and eosinophils, mast cells, basophils, eosinophils and keratinocytes that play an important role in AD etiopathogenesis. Impaired skin barrier is associated with decrease in filaggrin protein, increase in TEWL, lipid alterations and cutaneous dysbiosis. Abbreviations: APC, antigen presenting cell; IFN, interferon; Ig E, immunoglobulin E; IL, interleukin; ILC2, innate lymphoid cell 2; S.aureus, Staphylococcus aureus; TEWL, transepidermal water loss; Th, T helper; TSLP, thymic stromal lymphopoietin cell.
