Table 1.

Generation of Intraspecies Exogenic Organs and Cells.

Chimera type	Organs and cells generated	Gene knocked out	References
Mouse > Mouse	Immune system cells	RAG2	Chen et al. 26
		RAG	Young et al. 27
		c-KIT	Jansson and Larsson 28
		RUNX2	Chubb et al. 29
		FOXN1	Yamazaki et al. 30
	Lens	PITX3	Liégeois et al. 31
	Pancreas and islet cells	PDX1	Kobayashi et al. 32
	Kidney	SALL1	Usui et al. 33
	Liver	HHEX	Ruiz-Estevez et al. 34
	Lung	CTNNB1	Mori et al. 35
		FGFR2	Mori et al. 35
		FGF10	Kitahara et al. 36
		NKX2.1	Wen et al. 37 Li et al. 38
	Thyroid	FGF10	Ran et al. 39
	CNS and PNS	EMX1	Chang et al. 40
		DCX	Chang et al. 40
		NEUROG1	Steevens et al. 41
	Endothelial cells	VEGFR2	Hamanaka et al. 42
	Bone and skull	RUNX2	Chubb et al. 29
Pig > Pig	Pancreas and islet cells	PDX1	Matsunari et al. 43
	Liver	HHEX	Matsunari et al. 44 Ruiz-Estevez et al. 34
	Kidney	SALL1	Matsunari et al. 44
	Endothelial vasculature	FLK1	Matsunari et al. 44
		KDR	Matsunari et al. 44
	Retinal pigment epithelium	MITF	Zhang et al. 45
	Skin, heart, and kidney	WILD TYPE	Ji et al. 46
Cow > Cow	Germline	NANOS3	Ideta et al. 47

PNS: peripheral nervous system; CNS: central nervous system.