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. 2023 Aug 16;14:1247355. doi: 10.3389/fimmu.2023.1247355

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Copyright © 2023 Yan, Sun, Wang, Zhao, Yu, Zhang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Results of differences analysis between Fb and Fnb. (A) Differences in the proportion of cell subpopulations. (B) Differences in the number of cell subpopulations. (C) The PPI network constructed by the String tool. Nodes represented proteins produced by protein-coding genes, and connections between nodes represented predicted protein interactions. (D) The top 10 Hub genes predicted by Cytoscape. (E) Volcano plot of MC DEGs between Fb and Fnb groups. The horizontal coordinate in the plot represented logFC and the vertical coordinate represented p-values. (F–G) Results of GO and KEGG enrichment analysis of MC between Fb and Fnb groups. The size of the circle indicated the number of enriched DEGs and the color represented the p-value. Fb, femur weight-bearing region; Fnb, femur non-weight-bearing region; GO, gene ontology; CPC, cartilage progenitor cells; EC, effector chondrocyte; FC, fibrocartilage chondrocyte; IrC, inflammatory related chondrocyte; MC, macrophage chondrocyte; RegC, regulatory chondrocyte.