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. 2023 Aug 16;14:1247355. doi: 10.3389/fimmu.2023.1247355

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Copyright © 2023 Yan, Sun, Wang, Zhao, Yu, Zhang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Marker genes for Immune-related chondrocytes. (A) Clustering plot of three cell subpopulations. (B, C) DotPlot of the cell marker genes. (D) A scatter plot of the cell marker genes, with the color of the dots representing expression levels. (E) Venn diagram for cell ID comparison of IrC and IL32+. The overlap represented the number of repetitive cells in the subpopulation. (F) IHC results for marker genes in different groups and layers. Scale bar, left, 200 µm; right, 100 µm. The scores of the indicated genes in the cartilage of both regions based on the immunohistochemistry assay are shown. *p<0.05, **p<0.01; otherwise, not significant. CPC, cartilage progenitor cells; EC, effector chondrocyte; FC, fibrocartilage chondrocyte; IrC, inflammatory-related chondrocyte; MC, macrophage chondrocyte; RegC, regulatory chondrocyte.