6) Risultati economici a 50 anni (2070), per fascia d’età e per tutti gli scenari considerati, prospettiva della società
| Risultati caso base | Delta Caso base | ICERs | Delta Scenario 1 (scaled VE vs St 3) | ICERs | Delta Scenario 2 (VCRs = 75% negli adulti) | ICERs | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PCV15 vs PCv13 nei bambini | PCV15 anche negli adulti (PCV15 + PPSV23) | PCV15 vs PCv13 nei bambini | PCV15 negli adulti (PCV15 + PPSV23) | PCV15 vs PCv13 nei bambini | PCV15 negli adulti (PCV15 + PPSV23) | PCV15 vs PCv13 nei bambini | PCV15 negli adulti (PCV15 + PPSV23) | |||||
| Fascia d'età 0-1 | ||||||||||||
| Costo vaccino | 2.733.622.990 € | 2.733.622.990 € | 2.733.622.990 € | 0 € | 0 € | 0 € | 0 € | 0 € | 0 € | |||
| Costo MIP | 16.470.553 € | 13.407.577 € | 13.407.517 € | -3.062.977 € | -3.063.036 € | -3.815.469 € | -3.815.614 € | -3.062.845 € | -3.062.932 € | |||
| Costo batteriemie | 8.495.178 € | 6.915.357 € | 6.915.326 € | -1.579.821 € | -1.579.852 € | -1.967.941 € | -1.968.016 € | -1.579.754 € | -1.579.798 € | |||
| Costo meningiti | 7.975.375 € | 6.492.220 € | 6.492.191 € | -1.483.155 € | -1.483.184 € | -1.847.527 € | -1.847.598 € | -1.483.091 € | -1.483.133 € | |||
| Costo PMS | 1.136.308 € | 924.992 € | 924.988 € | -211.316 € | -211.320 € | -263.230 € | -263.240 € | -211.307 € | -211.313 € | |||
| Costo PNB | 18.615.002 € | 16.659.096 € | 16.659.229 € | -1.955.906 € | -1.955.773 € | -44.419 € | -44.031 € | -1.955.920 € | -1.955.733 € | |||
| Costo OMA | 9.118.018 € | 8.424.383 € | 8.424.432 € | -693.635 € | -693.586 € | 703.119 € | 703.351 € | -693.608 € | -693.537 € | |||
| LYs (discounted) | 18.893.597 | 18.893.602 | 18.893.602 | 5.252 | 5.252 | 7 | 7 | 5 | 5 | |||
| LYs (undiscounted) | 36.480.236 | 36.480.246 | 36.480.246 | 10.532 | 10.532 | 13 | 13 | 10 | 10 | |||
| Costo totale | 2.778.962.871 € | 2.773.039.038 € | 2.773.039.157 € | -5.923.833 € | -5.923.714 € | PCV15 dominante | -3.419.999 € | -3.419.534 € | PCV15 dominante | -5.923.679 € | -5.923.513 € | |
| QALYs guadagnati | 17.906.696 | 17.907.486 | 17.907.486 | 790 | 790 | 921 | 921 | 790 | 790 | PCV15 dominante | ||
| Fascia d'età 1-4 | ||||||||||||
| Costo vaccino | 0 € | 0 € | 0 € | 0 € | 0 € | 0 € | 0 € | 0 € | 0 € | |||
| Costo MIP | 58.010.373 € | 48.442.030 € | 48.441.760 € | -9.568.342 € | -9.568.613 € | -12.768.160 € | -12.768.812 € | -9.568.152 € | -9.568.541 € | |||
| Costo batteriemie | 29.920.578 € | 24.985.420 € | 24.985.280 € | -4.935.158 € | -4.935.297 € | -6.585.559 € | -6.585.896 € | -4.935.059 € | -4.935.259 € | |||
| Costo meningiti | 28.089.795 € | 23.456.610 € | 23.456.479 € | -4.633.185 € | -4.633.316 € | -6.182.601 € | -6.182.917 € | -4.633.093 € | -4.633.281 € | |||
| Costo PMS | 4.047.385 € | 3.379.802 € | 3.379.783 € | -667.583 € | -667.602 € | -890.835 € | -890.880 € | -667.570 € | -667.597 € | |||
| Costo PNB | 132.956.376 € | 117.627.941 € | 117.628.632 € | -15.328.435 € | -15.327.744 € | -2.952.420 € | -2.950.130 € | -15.328.690 € | -15.327.717 € | |||
| Costo OMA | 37.281.283 € | 34.269.863 € | 34.270.002 € | -3.011.420 € | -3.011.280 € | 1.778.812 € | 1.779.567 € | -3.011.362 € | -3.011.159 € | |||
| LYs (discounted) | 75.445.865 | 75.445.895 | 75.445.895 | 30.365 | 30.366 | 40 | 40 | 30 | 30 | |||
| LYs (undiscounted) | 145.672.762 | 145.672.823 | 145.672.823 | 61.197 | 61.200 | 86 | 86 | 61 | 61 | |||
| Costo totale | 232.295.416 € | 203.719.636 € | 203.720.177 € | -28.575.780 € | -28.575.239 € | -14.832.601 € | -14.830.255 € | -28.575.775 € | -28.575.015 € | |||
| QALYs guadagnati | 71.505.455 | 71.508.151 | 71.508.151 | 2.697 | 2.697 | PCV15 dominante | 3.138 | 3.138 | PCV15 dominante | 2.697 | 2.697 | PCV15 dominante |
| Fascia d'età 5-14 | ||||||||||||
| Costo vaccino | 0 € | 0 € | 0 € | 0 € | 0 € | 0 € | 0 € | 0 € | 0 € | |||
| Costo MIP | 37.453.752 € | 31.128.303 € | 31.128.020 € | -6.325.449 € | -6.325.731 € | -8.688.617 € | -8.689.167 € | -6.324.767 € | -6.325.170 € | |||
| Costo batteriemie | 19.317.888 € | 16.055.349 € | 16.055.204 € | -3.262.539 € | -3.262.684 € | -4.481.413 € | -4.481.696 € | -3.262.187 € | -3.262.394 € | |||
| Costo meningiti | 18.135.864 € | 15.072.953 € | 15.072.817 € | -3.062.910 € | -3.063.047 € | -4.207.204 € | -4.207.471 € | -3.062.580 € | -3.062.775 € | |||
| Costo PMS | 2.585.206 € | 2.148.598 € | 2.148.579 € | -436.608 € | -436.627 € | -599.723 € | -599.761 € | -436.561 € | -436.589 € | |||
| Costo PNB | 113.601.810 € | 102.127.713 € | 102.127.561 € | -11.474.097 € | -11.474.249 € | -6.895.542 € | -6.895.064 € | -11.474.397 € | -11.474.609 € | |||
| Costo OMA | 23.199.884 € | 21.592.532 € | 21.592.439 € | -1.607.353 € | -1.607.445 € | -952.623 € | -952.601 € | -1.607.369 € | -1.607.494 € | |||
| LYs (discounted) | 188.412.617 | 188.412.627 | 188.412.627 | 10.566 | 10.581 | 13 | 15 | 10 | 10 | |||
| LYs (undiscounted) | 363.791.659 | 363.791.679 | 363.791.679 | 20.594 | 20.595 | 29 | 29 | 20 | 20 | |||
| Costo totale | 176.840.652 € | 156.997.146 € | 156.996.599 € | -19.843.506 € | -19.844.053 € | -17.136.504 € | -17.136.593 € | -19.843.093 € | -19.843.860 € | |||
| QALYs guadagnati | 178.603.762 | 178.605.494 | 178.605.494 | 1.732 | 1.732 | PCV15 dominante | 2.147 | 2.147 | PCV15 dominante | 1.732 | 1.732 | PCV15 dominante |
| Fascia d'età 15-64 | ||||||||||||
| Costo vaccino | 243.675.053 € | 243.675.484 € | 243.675.497 € | 430 € | 443 € | 737 € | 751 € | 431 € | 444 € | |||
| Costo MIP | 246.230.674 € | 230.989.183 € | 228.458.120 € | -15.241.491 € | -17.772.554 € | -27.731.991 € | -30.527.107 € | -15.242.132 € | -17.775.932 € | |||
| Costo batteriemie | 162.070.299 € | 152.038.274 € | 150.372.314 € | -10.032.025 € | -11.697.985 € | -18.253.339 € | -20.093.098 € | -10.032.448 € | -11.700.211 € | |||
| Costo meningiti | 84.160.375 € | 78.950.910 € | 78.085.806 € | -5.209.466 € | -6.074.569 € | -9.478.652 € | -10.434.008 € | -5.209.684 € | -6.075.721 € | |||
| Costo PMS | 13.321.380 € | 12.496.797 € | 12.359.863 € | -824.583 € | -961.517 € | -1.500.334 € | -1.651.554 € | -824.618 € | -961.700 € | |||
| Costo PNB | 706.177.908 € | 679.085.872 € | 674.589.331 € | -27.092.036 € | -31.588.577 € | 31.765.484 € | 26.809.410 € | -27.090.386 € | -31.592.613 € | |||
| Costo OMA | 0 € | 0 € | 0 € | 0 € | 0 € | 0 € | 0 € | 0 € | 0 € | |||
| LYs (discounted) | 902.619.264 | 902.619.389 | 902.619.410 | 125 | 146 | 155 | 178 | 125 | 146 | |||
| LYs (undiscounted) | 1.742.792.424 | 1.742.792.695 | 1.742.792.738 | 271 | 314 | 347 | 395 | 271 | 314 | |||
| Costo totale | 1.209.405.016 € | 1.166.247.336 € | 1.159.082.811 € | -43.157.679 € | -50.322.204 € | 2.533.895 € | -5.368.500 € | -43.156.705 € | -50.329.801 € | |||
| QALYs guadagnati | 826.748.865 | 826.751.757 | 826.752.238 | 2.892 | 3.373 | PCV15 dominante | 3.540 | 4.070 | PCV15 costo-efficace a 716 | 2.892 | 3.373 | PCV15 dominante |
| Fascia d'età 65+ | ||||||||||||
| Costo vaccino | 254.567.187 € | 254.569.297 € | 254.569.301 € | 2.110 € | 2.114 € | 3.904 € | 3.909 € | 368 € | 369 € | |||
| Costo MIP | 336.707.266 € | 316.644.141 € | 314.646.841 € | -20.063.124 € | -22.060.425 € | -37.790.398 € | -39.985.829 € | -14.028.289 € | -16.098.757 € | |||
| Costo batteriemie | 221.622.459 € | 208.416.807 € | 207.102.173 € | -13.205.652 € | -14.520.286 € | -24.873.835 € | -26.318.879 € | -9.233.494 € | -10.596.286 € | |||
| Costo meningiti | 115.084.807 € | 108.227.334 € | 107.544.668 € | -6.857.473 € | -7.540.139 € | -12.916.564 € | -13.666.950 € | -4.794.796 € | -5.502.471 € | |||
| Costo PMS | 6.664.439 € | 6.267.330 € | 6.227.798 € | -397.109 € | -436.641 € | -747.985 € | -791.439 € | -277.661 € | -318.642 € | |||
| Costo PNB | 3.493.122.516 € | 3.333.923.947 € | 3.319.041.536 € | -159.198.569 € | -174.080.980 € | 6.674.754 € | -9.679.973 € | -145.403.776 € | -166.177.634 € | |||
| Costo OMA | 0 € | 0 € | 0 € | 0 € | 0 € | 0 € | 0 € | 0 € | 0 € | |||
| LYs (discounted) | 363.384.198 | 363.386.570 | 363.386.794 | 2.372 | 2.596 | 378 | 622 | 2116 | 2418 | |||
| LYs (undiscounted) | 701.619.008 | 701.624.291 | 701.624.796 | 5.284 | 5.789 | 636 | 1.186 | 4731 | 5373 | |||
| Costo totale | 4.091.061.408 € | 3.911.404.716 € | 3.894.485.476 € | -179.656.692 € | -196.575.933 € | -31.859.725 € | -50.453.332 € | -159.709.359 € | -182.594.665 € | |||
| QALYs guadagnati | 280.795.816 | 280.802.413 | 280.803.036 | 6.597 | 7.220 | PCV15 dominante | 1.703 | 2.388 | PCV15 dominante | 5.805 | 6.638 | PCV15 dominante |
| Tutte le età | ||||||||||||
| Costo vaccino | 3.231.865.231 € | 3.231.867.771 € | 3.231.867.788 € | 2.540 € | 2.557 € | 4.640 € | 4.659 € | 799 € | 813 € | |||
| Costo MIP | 694.872.618 € | 640.611.235 € | 636.082.259 € | -54.261.384 € | -58.790.359 € | -90.794.635 € | -95.786.529 € | -48.226.185 € | -52.831.330 € | |||
| Costo batteriemie | 441.426.402 € | 408.411.208 € | 405.430.297 € | -33.015.195 € | -35.996.105 € | -56.162.087 € | -59.447.586 € | -29.042.942 € | -32.073.948 € | |||
| Costo meningiti | 253.446.216 € | 232.200.027 € | 230.651.961 € | -21.246.189 € | -22.794.254 € | -34.632.548 € | -36.338.944 € | -19.183.244 € | -20.757.382 € | |||
| Costo PMS | 27.754.718 € | 25.217.519 € | 25.041.010 € | -2.537.199 € | -2.713.707 € | -4.002.107 € | -4.196.874 € | -2.417.717 € | -2.595.840 € | |||
| Costo PNB | 4.464.473.612 € | 4.249.424.570 € | 4.230.046.289 € | -215.049.042 € | -234.427.323 € | 28.547.856 € | 7.240.212 € | -201.253.168 € | -226.528.306 € | |||
| Costo OMA | 69.599.185 € | 64.286.778 € | 64.286.874 € | -5.312.407 € | -5.312.311 € | 1.529.309 € | 1.530.317 € | -5.312.339 € | -5.312.190 € | |||
| LYs (discounted) | 1.548.755.540 | 1.548.758.084 | 1.548.758.328 | 2.544 | 2.788 | 594 | 863 | 2287 | 2610 | |||
| LYs (undiscounted) | 2.990.356.088 | 2.990.361.735 | 2.990.362.283 | 5.647 | 6.195 | 1112 | 1.710 | 5095 | 5780 | |||
| Costo totale | 8.488.565.364 € | 8.211.407.872 € | 8.187.324.220 € | -277.157.492 € | -301.241.143 € | -64.714.936 € | -91.208.216 € | -257.208.611 € | -287.266.854 € | |||
| QALYs guadagnati | 1.375.560.594 | 1.375.575.302 | 1.375.576.405 | 14.708 | 15.811 | PCV15 dominante | 11.449 | 12.664 | PCV15 dominante | 13.916 | 15.230 | PCV15 dominante |