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. Author manuscript; available in PMC: 2024 Sep 1.
Published in final edited form as: Epidemiology. 2023 Jul 31;34(5):661–672. doi: 10.1097/EDE.0000000000001643

Table 4.

Parameter settings under four simulation scenarios.

Scenario Product terms in mediator and outcome models θ3 β3 θ5 θ6

1 A×M in outcome model {0, 0.5, 0.8} 0 0 0
2 A×M in outcome model, A×C in mediator model 0.5 {0.1, 0.4, 0.7} 0 0
3 A×M in outcome model, A×C in mediator model, A×C in outcome model 0.5 0.2 {0.2, 0.5, 0.8} 0
4 A×M in outcome model, A×C in mediator model, A×C in outcome model, M×C in outcome model 0.5 0.2 0.3 {0.3, 0.6, 0.9}

Coefficients.

θ3: A×M causal interaction in outcome model

β3: A×C effect measure modification in mediator model

θ5: A×C effect measure modification in outcome model

θ6: M×C effect measure modification in outcome model