Table 6.
Results of mediation analyses for the CANTOS trial example.
| Subgroup | Effect | Point Estimate | 95% CI |
|---|---|---|---|
|
| |||
| Lower anemia risk profilea | NDE | 1.149 | (0.951, 1.388) |
| NIE | 1.230 | (1.137, 1.330) | |
| TE | 1.413 | (1.182, 1.689) | |
| PM | 63.96% | (30.05%, 97.87%) | |
|
| |||
| Higher anemia risk profileb | NDE | 1.210 | (1.012, 1.447) |
| NIE | 1.164 | (1.065, 1.273) | |
| TE | 1.409 | (1.162, 1.708) | |
| PM | 48.65% | (21.06%, 76.23%) | |
Abbreviations. EMM: effect measure modification; NDE: natural direct effect; NIE: natural indirect effect; PM: proportion mediated; CI: confidence interval.
The effects are on the mean time ratio scale, a value greater than 1.0 indicates a protective effect of canakinumab on the incident anemia outcome.
a
: Conditioning on 25th percentile value of age, 25th percentile value of baseline logarithm of high-sensitivity C-reactive protein, and having no diabetes.
b
: Conditioning on 75th percentile value of age, 75th percentile value of logarithm of high-sensitivity C-reactive protein, and having diabetes.