Table 4. Serum high-density lipoprotein cholesterol levels according to CETP-TaqIB genotype by status of smoking (only men) and alcohol drinking and tertiles of active intensity index (AII).

	Nonsmokers		Smokers		Nondrinkers		Drinkers		Tertile 1 of AII		Tertile 2 of AII		Tertile 3 of AII
	n	LSM (SE)	n	LSM (SE)	n	LSM (SE)	n	LSM (SE)	n	LSM (SE)	n	LSM (SE)	n	LSM (SE)
HDL-C, mg/dl
Men
B1B1	43	53.4 (2.0)	46	51.7 (1.5)	17	44.4 (2.4)	72	54.6 (1.4)	34	49.5 (1.9)	21	57.1 (2.4)	34	53.5 (2.2)
B1B2	59	59.4 (1.7)‡	75	55.0 (1.2)	29	50.4 (1.8)	105	58.1 (1.2)	50	56.5 (1.6)‡	43	57.4 (1.7)	41	57.0 (2.0)
B2B2	14	61.7 (3.6)*	19	58.2 (2.4)*	2	57.5 (7.7)	31	61.7 (2.2)*	29	55.3 (2.9)	5	58.5 (5.2)	13	63.2 (3.5)
P for trenda		0.043		0.052		0.075		0.017		0.020		0.973		0.071
Pb				0.914				0.503				0.454
women
B1B1					68	60.8 (1.4)	23	62.3 (2.8)	32	59.4 (2.3)	33	61.9 (2.2)	26	62.5 (2.4)
B1B2					90	62.0 (1.2)	48	67.4 (1.9)	37	61.5 (2.1)	56	65.1 (1.7)	45	64.5 (1.8)
B2B2					27	62.6 (2.2)	15	71.5 (3.5)	14	63.8 (3.5)	16	63.3 (3.1)	12	70.6 (3.5)
P for trenda						0.743		0.154		0.655		0.511		0.181
Pb								0.222				0.399

Values are Least-Square Means (SE) adjusted for the age, log BMI, smoking (except status of smoking), alcohol drinking (expect status of alcohol drinking), AII (expect tertiles of active intensive index), fasting triglyceride (expect TG).

Tertile 1=1.50 to <1.83 METs; Tertile 2=1.83 to <2.07 METs; Tertile 3=2.07 to 3.84 METs.

Shown at significant differences between B2B2 and B1B1 (*), B2B2 and B1B2 (†), and B2B1 and B1B1 (‡).

^a The number of alleles 2 (coded as 0, 1, 2) and tertiles of AII (coded as 1, 2, 3) are used as continuous independent variables. Smoking or alcohol drinking status is coded as 0, 1.

^b Test for the interactions between CETP-TaqIB genotype and each of smoking, alcohol drinking, and AII.