Table 2. Number of Cases and Controls, Odds Ratios (OR) and 95% CIs, for ALDH2 polymorphisms.

Genotype	Males						Female
	Controls	Cases	Model*2 1		Model 2		Controls	Cases	Model 1		Model 2
			OR	95%CI	OR	95%CI			OR	95%>CI	OR	95%CI
All cases	N=118	N=83					N=123	N=59
Glu/Glu	65(55.1%)	53(63.9%)	1.00	Reference	1.00	Reference	61(49.6%)	28(47.5%)	1.00	Reference	1.00	Reference
Glu/Lys	44(37.3%)	26(31.3%)	0.72	0.40-1.33	0.70	0.38-1.30	52(42.3%)	28(47.5%)	1.17	0.62-2.23	1.11	0.58-2.14
Lys/Lys	9(7.6%)	3(3.6%)	0.41	0.11-1.59	0.38	0.10-1.51	10(8.1%)	3(5.1%)	0.65	0.17-2.56	0.63	0.16-2.48
UK*1	0(0.0%)	1(1.2%)	-				0(0.0%)	0(0.0%)
Colon cancer	N=118	N=42					N=123	N=30
Glu/Glu	65(55.1%)	31(73.8%)	1.00	Reference	1.00	Reference	61(49.6%)	17(56.7%)	1.00	Reference	1.00	Reference
Glu/Lys	44(37.3%)	10(23.8%)	0.48	0.21-1.07	0.47	0.21-1.06	52(42.3%)	12(40.0%)	0.83	0.36-1.89	0.78	0.33-1.83
Lys/Lys	9(7.6%)	1(2.4%)	0.23	0.03-1.92	0.22	0.03-1.85	10(8.1%)	1(3.3%)	0.36	0.04-3.00	0.38	0.05-3.30
Rectal cancer	N=118	N=41					N=123	N=29
Glu/Glu	65(55.1%)	22(53.7%)	1.00	Reference	1.00	Reference	61(49.6%)	11(37.9%)	1.00	Reference	1.00	Reference
Glu/Lys	44(37.3%)	16(39.0%)	1.07	0.51-2.27	1.11	0.51-2.38	52(42.3%)	16(55.2%)	1.71	0.73-4.00	1.61	0.26-4.31
Lys/Lys	9(7.6%)	2(4.9%)	0.66	0.13-2.27	0.65	0.12-3.35	10(8.1%)	2(6.9%)	1.11	0.21-5.77	1.03	0.20-5.39
UK	0(0.0%)	1(2.4%)	-				0(0.0%)	0(0.0%)

*¹ UK indicates ALDH2 genotype unknown because DNA was not amplified by PCR. This subject was excluded from OR analyses.

*² Model 1: crude OR. Model 2: adjusted for age and smoking status.

Alcohol consumption was not adjusted because of strong confounding with ALDH2 genotype.