Table 3. Adjusted*¹ ORs and 95% CIs for alcohol drinking according to ALDH2 genotype.

Alcohol consumption	Controls	All cases			Colon cancer			Rectal cancer
			OR	95%CI		OR	95%CI		OR	95%CI
Total	N=240*2	N=141*3			N=72			N=69*3
ALDH2 487 Glu/Glu
	N=126	N=81			N=48			N=33
Low	54(42.9%)	25(30.9%)	1.00	Reference	17(35.4%)	1.00	Reference	8(24.2%)	1.00	Reference
Moderate	40(31.7%)	24(29.6%)	1.15	0.51-2.63	15(31.3%)	0.94	0.35-2.47	9(27.3%)	1.53	0.46-5.13
High	32(25.4%)	32(39.5%)	1.92	0.77-4.80	16(33.3%)	1.21	0.41-3.52	16(48.5%)	3.41	0.92-12.6
		P for trend:	0.138			0.693			0.050
ALDH2 487 Glu/Lys
	N=95	N=54			N=22			N=32
Low	64(67.4%)	35(64.8%)	1.00	Reference	17(77.3%)	1.00	Reference	18(56.3%)	1.00	Reference
Moderate	26(27.4%)	10(18.5%)	0.76	0.30-1.98	4(18.2%)	0.53	0.14-1.97	6(18.8%)	1.08	0.33-3.54
High	5(5.3%)	9(16.7%)	3.59	0.99-13.0	1(4.6%)	0.69	0.07-6.89	8(25.0%)	8.07	1.88-34.7
		P for trend:	0.155			0.436			0.013
ALDH2 487 Lys/Lys
	N=19	N=6			N=2			N=4
Low	18(94.8%)	4(66.7%)	1.00	Reference	1(50.0%)	1.00	Reference	3(75.0%)	1.00	Reference
Moderate	1(5.2%)	2(33.3%)	24.5	0.77-786.7	1(50.0%)	18.2*4	0.58-569.7	1(25.0%)	7.44	0.22-256.1
High	0(0.0%)	0(0.0%)	NE*3		0(0.0%)	NE*5		0(0.0%)	NE*5
		P for trend:	0.070			NE*4			0.744
Male	N=118	N=82*3			N=42			N=40*3
ALDH2 487 Glu/Glu
	N=65	N=53			N=31			N=22
Low	8(12.3%)	5(9.4%)	1.00	Reference	4(12.9%)	1.00	Reference	1 (4.5%)	1.00	Reference
Moderate	28(43.1%)	18(34.0%)	1.04	0.29-3.70	12(38.7%)	0.88	0.22-3.49	6(27.3%)	1.68	0.18-16.2
High	29(44.6%)	30(56.6%)	1.69	0.49-5.84	15(48.4%)	1.07	0.27-4.17	15(68.2%)	4.00	0.45-35.5
		P for trend:	0.230			0.795			0.072
ALDH2 487 Glu/Lys
	N=44	N=26			N=10			N=16
Low	19(43.2%)	9(34.6%)	1.00	Reference	5(50.0%)	1.00	Reference	8(50.0%)	1.00	Reference
Moderate	21(47.7%)	8(30.8%)	0.84	0.27-2.68	4(40.0%)	0.74	0.17-3.19	4(25.0%)	0.99	0.33-3.54
High	4(9.1%)	9(34.6%)	5.07	1.19-21.6	1(10.0%)	0.97	0.09-10.9	4(25.0%)	13.2	2.24-78.0
		P for trend:	0.057			0.817			0.004
ALDH2 487 Lys/Lys
	N=9	N=3			N=1			N=2
Low	8(88.9%)	1(66.7%)	1.00	Reference	0(0.0%)	1.00	Reference	1(50.0%)	1.00	Reference
Moderate	1(11.1%)	2(33.3%)	16.0	0.65-390.9	1(100.0%)	NE*5		1(50.0%)	7.39	0.22-248.5
High	0(0.0%)	0(0.0%)	NE*4		0(0.0%)	NE*5		0(0.0%)	NE*5
		P for trend:	0.090			NE*5			0.265
Female	N=123*2	N=59			N=30			N=29
ALDH2 487 Glu/Glu
	N=61	N=28			N=17			N=11
Low	46(75.4%)	20(71.4%)	1.00	Reference	13(76.5%)	1.00	Reference	7 (63.6%)	1.00	Reference
Moderate	12(19.7%)	6(21.4%)	1.32	0.42-4.15	3(17.7%)	0.97	0.22-4.34	3(27.3%)	1.69	0.37-7.75
High	3(4.9%)	2(7.1%)	2.75	0.37-20.8	1(5.9%)	2.30	0.18-29.1	1(9.1%)	2.44	0.18-32.8
		P for trend:	0.331			0.679			0.390
ALDH2 487 Glu/Lys
	N=51	N=28			N=12			N=16
Low	45(88.2%)	26(92.9%)	1.00	Reference	12(100.0%)	1.00	Reference	14(87.5%)	1.00	Reference
Moderate	5(9.8%)	2(7.1%)	0.69	0.12-3.91	0(0.0%)	NE*5		2(12.5%)	1.26	0.20-7.58
High	1(2.0%)	0(0.0%)	NE*5		0(0.0%)	NE*5		0(0.0%)	NE*5
		P for trend:	0.445			NE*5			0.891
ALDH2 487 Lys/Lys
	N=10	N=3			N=1			N=2
Low	10(100.0%)	3(100.0%)	1.00	Reference	1(100.0%)	1.00	Reference	2(100.0%)	1.00	Reference
Moderate	0(0.0%)	0(33.3%)	NE*5		0(0.0%)	NE*5	0.58-569.7	0(0.0%)	NE*5
High	0(0.0%)	0(0.0%)	NE*5		0(0.0%)	NE*5		0(0.0%)	NE*5
		P for trend:	NE*5			NE*5			NE*5

*¹ For overall analyses, sex and age were adjusted. Age was adjusted in analyses for each sex.

*² One controls was excluded from analysis because alcohol consumption data was not completed.

*³ One case was excluded from analysis because ALDH2 genotype was not determined.

*⁴ Adjusted OR for only age because subjects’ sex for Lys/Lys genotype and moderate drinking was male.

*⁵ NE indicates not estimated because case or controls were absent in these categories.