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. 2023 Aug 30;14(8):577. doi: 10.1038/s41419-023-06104-4

Fig. 1. Fcn B from macrophages aggravated BLM-induced lung injury and fibrosis.

Fig. 1

A The concentrations of L-ficolin and M-ficolin in plasma were measured by biochemical kits. *ILD vs. Healthy control, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. B The Survival curves of mice after BLM induction. C The histopathological changes in the lung were observed by HE staining. D Pulmonary interstitial fibrosis was detected by Masson staining. E, F The concentrations of total protein in BALF and hydroxyproline in lung were determined by biochemical kits. G The expression level of α-SMA in lung was detected by Western blot. H, I The percentage of Fcn B positive cells in lung macrophages and neutrophils was detected by flow cytometry. The experiment was repeated three times (n = 10 mice/group). The data were presented as the mean ± SD. *WT+BLM vs. WT, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; #Fcnb-/-+BLM vs. WT+BLM, #P < 0.05, ##P < 0.01, ###P < 0.001, ####P < 0.0001.