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. 2023 Aug 30;14(8):577. doi: 10.1038/s41419-023-06104-4

Fig. 2. Fcn B promoted BLM-induced autophagy and ferroptosis in lung.

Fig. 2

A The expressions of LC3II/LC3I, Beclin1, ATG7, and p62 in lung were detected by Western blot. B The concentrations of MDA, GSH, and Fe2+ in lung and serum were detected by biochemical kits. C ROS levels in lung were determined by flow cytometry. D, E The expressions of GPX4, SLC7A11, FTH1, FTL1, and NCOA4 in lung were detected by Western blot. The experiment was repeated three times (n = 10 mice/group). The data were presented as the mean ± SD. *WT+BLM vs. WT, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; #Fcnb-/-+BLM vs. WT+BLM, #P < 0.05, ##P < 0.01, ###P < 0.001, ####P < 0.0001.