Fig. 7. Fcn B transported from AMs exosomes facilitated lung injury and fibrosis in BLM-induced mice model.

A The histopathological changes in the lung were observed by HE staining. B Pulmonary interstitial fibrosis was detected by Masson staining. C, D The concentrations of total protein in BALF and hydroxyproline in the lung were determined by biochemical kits. E The expression of α-SMA in lung was detected by Western blot. The experiment was repeated three times (n = 10 mice/group). The data were presented as the mean ± SD. * WT+BLM vs. WT, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; ^$WT+BLM+Exo^oe-NC vs. WT+BLM, ^$P < 0.05, ^$$P < 0.01, ^$$$P < 0.001, ^$$$$P < 0.0001; & WT+BLM+Exo^oe-Fcnb vs. WT+BLM+Exo^oe-NC, ^&P < 0.05, ^&&P < 0.01, ^&&&P < 0.001, ^&&&&P < 0.0001; ^#Fcnb^-/-+BLM vs. WT+BLM, ^#P < 0.05, ^##P < 0.01, ^###P < 0.001, ^####P < 0.0001; @ Fcnb^-/-+BLM+Exo^oe-NC vs. Fcnb^-/-+BLM, ^@P < 0.05, ^@@P < 0.01, ^@@@P < 0.001, ^@@@@P < 0.0001; Δ Fcnb^-/-+BLM+Exo^oe-Fcnb vs. Fcnb^-/-+BLM+Exo^oe-NC, ^ΔP < 0.05, ^ΔΔP < 0.01, ^ΔΔΔP < 0.001, ^ΔΔΔΔP < 0.0001.