Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Aug 30;13(9):e1393. doi: 10.1002/ctm2.1393

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Biogenesis mechanism of small eccDNAs in cancer tissues. (A) Nucleotide motif sequences flanking the start and end positions of small eccDNAs in non‐cancer (NC) and cancer (C) tissues. (B) Integrative Genomics Viewer (IGV) alignments showing small eccDNAs from two genomic loci on chromosomes 3 and 6 in the same tissue sample (C52) as an example. Individual horizontal bars in the same colour represent subreads from a unique long read that are originated from the same genomic locus. Different colours represent different raw reads, and the number of lines represents the number of tandem repeats. ecc‐1, ecc‐2 and ecc‐3 are single‐fragment circles. ecc‐4/ecc‐5 consists of ecc‐1 and ecc‐2/ecc‐3. Chr, chromosome. (C) IGV alignments showing small eccDNA examples from mitochondrial and genomic loci. MT, mitochondria.