Comparison 1. Non‐physiological neutral amino acid versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1.1 Fatigue	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
1.1.1 Haemodialysis	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
1.2 Change in fatigue	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
1.2.1 Haemodialysis	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
1.3 Number with improvement of fatigue	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
1.3.1 Haemodialysis	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
1.4 Number with aggravation of fatigue	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
1.4.1 Haemodialysis	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
1.5 Death (any cause)	3		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.5.1 Haemodialysis	3	0	Risk Ratio (M‐H, Random, 95% CI)	Not estimable
1.6 Cardiovascular death	2		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.6.1 Haemodialysis	2	0	Risk Ratio (M‐H, Random, 95% CI)	Not estimable
1.7 Quality of life (overall)	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
1.7.1 Haemodialysis	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
1.8 Change in quality of life	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
1.8.1 Haemodialysis	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
1.9 Depresssion	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
1.9.1 Haemodialysis	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
1.10 Change in depression	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
1.10.1 Haemodialysis	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
1.11 Hypertension	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
1.11.1 Haemodialysis	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected