van der Veen 2021.

Study name	A clinical approach of intradialytic creatine supplementation in dialysis‐dependent CKD patients: a rationale and study design
Methods	Study design RCT Duration of follow‐up: 6 weeks
Participants	Study characteristics Country: not reported Setting: not reported Inclusion criteria ≥ 18 years Undergoing maintenance HD Exclusion criteria Not reported
Interventions	Intervention group 1 Intradialytic creatine supplementation (0.5 mM) Intervention group 2 Intradialytic creatine supplementation (1.0 mM) Intervention group 3 Intradialytic creatine supplementation (1.5 mM) Intervention group 4 Intradialytic creatine supplementation (2.0 mM) Placebo group Placebo Co‐interventions Not reported
Outcomes	Planned outcomes Plasma creatine concentration and intra‐erythrocytic creatine concentration Handgrip strength Dialysate excretion of creatinine as a measure of muscle mass Body composition measured with bioelectrical impedance analysis
Starting date	Not reported
Contact information	Van Der Veen, Y. Phone: not reported Email: not reported
Notes	Trial Registeration Numbrer: not reported. Funding: not reported. Recruitment status: not reported

6‐minute walking test; AIDS: acquired immunodeficiency syndrome; ALP: alkaline phosphatase; BDI: Beck Depression Inventory; BFI: Brief Fatigue Inventory; BIA: Bioelectrical Impedance Analysis; BMI: body mass index; BP: blood pressure; BPI: Brief Pain Inventory; CBT: Cognitive‐behavior therapy; CEQ: Credibility Expectancy Questionnaire; CFQ: Chalder Fatigue Questionnair; CIS: Checklist Individual Strength; CKD: chronic kidney disease; CRP: C‐reactive protein; DBP: diastolic blood pressure; ESA: erythropoiesis stimulating agents; ESKD: end‐stage kidney disease; FACIT: Functional Assessment of Chronic Illness Therapy; HADS: Hospital Anxiety and Depression Scale; Hb: haemoglobin; HCT: haematocrit; HDF: haemodiafiltration; HRQoL: health‐related quality of life; IPAQ: International Physical Activity Questionnaire; KDQoL‐SF: Kidney Disease and Quality of Life Short form; Kt/V: dialyser urea clearance adequacy; MAQ: Medication Adherence Questionnaire; PD: peritoneal dialysis; PHQ‐9: Patient Health Questionnaire‐9; PSQI: Pittsburgh Sleep Quality Index; PTH: parathyroid hormone; QoL: quality of life; RBC: red blood cells; RCT: randomised controlled trial; SBP: systolic blood pressure; SF‐36: 36‐Item Short Form Health Survey; SONG‐HD: Standard Outcomes in Nephrology‐Haemodialysis; TSAT: transferrin saturation; VAS: visual analogue scale