Table 2.
Univariate and multivariate Cox regression analysis of TCIRG1 expression classifier and clinical characteristics with Overall Survival and Progression Free Interval in training cohort (n = 262)
| Characteristics | Overall survival | Progression Free Interval | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | |||||||||
| HR (95%CI) | p Value | HR (95%CI) | p Value | HR (95%CI) | p Value | HR(95%CI) | p Value | |||||
|
Age (≥ 60 vs. < 60) |
1.836(1.155–2.918) | 0.010 | 1.626(1.018–2.596) | 0.042 | 1.317(0.831–2.087) | 0.242 | ||||||
|
Gender (Male vs. Female) |
1.121(0.695–1.808) | 0.639 | 1.891(1.088–3.288) | 0.024 | 1.944(1.106–3.417) | 0.021 | ||||||
|
TNM stage (III-IV vs. I-II) |
3.262(2.060–5.166) | < 0.001 | 2.248(1.365–3.701) | 0.001 | 6.314(3.738–10.664) | < 0.001 | 5.197(2.977–9.072) | < 0.001 | ||||
|
Pathological grade (III-IV vs. I-II) |
2.800(1.673–4.687) | < 0.001 | 1.766(1.016–3.701) | 0.044 | 4.079(2.276–7.308) | < 0.001 | 2.340(1.284–4.267) | 0.006 | ||||
|
TCIRG1 expression (High vs. Low) |
2.409(1.554–3.736) | < 0.001 | 1.679(1.061–2.658) | 0.027 | 2.085(1.319–3.297) | 0.002 | 1.315(0.813–2.126) | 0.265 | ||||
* TCIRG1 was divided into high and low expression groups with an optimal cutoff value of 3.82
TCIRG1 low expression: Gene expression level of TCIRG1 < 3.82;
TCIRG1 high expression: Gene expression level of TCIRG1 ≥ 3.82;
Statistical significance was calculated by Chi squared test or Fisher’s exact test for categorical/binary measures
Abbreviation: ccRCC, clear cell renal cell carcinoma